Robust Transceiver Design Based on Interference Alignment for Multi-User Multi-Cell MIMO Networks with Channel Uncertainty

In this paper, we firstly exploit the inter-user interference (IUI) and inter-cell interference (ICI) as useful references to develop a robust transceiver design based on interference alignment for a downlink multi-user multi-cell multiple-input multiple-output (MIMO) interference network under channel estimation error. At transmitters, we propose a two-tier transmit beamforming strategy, we first achieve the inner beamforming direction and allocated power by minimizing the interference leakage as well as maximizing the system energy efficiency, respectively. Then, for the outer beamformer design, we develop an efficient conjugate gradient Grassmann manifold subspace tracking algorithm to minimize the distances between the subspace spanned by interference and the interference subspace in the time varying channel. At receivers, we propose a practical interference alignment based on fast and robust fast data projection method (FDPM) subspace tracking algorithm, to achieve the receive beamformer under channel uncertainty. Numerical results show that our proposed robust transceiver design achieves better performance compared with some existing methods in terms of the sum rate and the energy efficiency.Comment: 12 pages, 8 figure

Advanced NOMA Assisted Semi-Grant-Free Transmission Schemes for Randomly Distributed Users

Non-orthogonal multiple access (NOMA) assisted semi-grant-free (SGF) transmission has recently received significant research attention due to its outstanding ability of serving grant-free (GF) users with grant-based (GB) users' spectrum, {\color{blue}which can greatly improve the spectrum efficiency and effectively relieve the massive access problem of 5G and beyond networks. In this paper, we investigate the performance of SGF schemes under more practical settings.} Firstly, we study the outage performance of the best user scheduling SGF scheme (BU-SGF) by considering the impacts of Rayleigh fading, path loss, and random user locations. Then, a fair SGF scheme is proposed by applying cumulative distribution function (CDF)-based scheduling (CS-SGF), which can also make full use of multi-user diversity. Moreover, by employing the theories of order statistics and stochastic geometry, we analyze the outage performances of both BU-SGF and CS-SGF schemes. Results show that full diversity orders can be achieved only when the served users' data rate is capped, which severely limit the rate performance of SGF schemes. To further address this issue, we propose a distributed power control strategy to relax such data rate constraint, and derive closed-form expressions of the two schemes' outage performances under this strategy. Finally, simulation results validate the fairness performance of the proposed CS-SGF scheme, the effectiveness of the power control strategy, and the accuracy of the theoretical analyses.Comment: 41 pages, 8 figure

Outage Performance of Uplink Rate Splitting Multiple Access with Randomly Deployed Users

With the rapid proliferation of smart devices in wireless networks, more powerful technologies are expected to fulfill the network requirements of high throughput, massive connectivity, and diversify quality of service. To this end, rate splitting multiple access (RSMA) is proposed as a promising solution to improve spectral efficiency and provide better fairness for the next-generation mobile networks. In this paper, the outage performance of uplink RSMA transmission with randomly deployed users is investigated, taking both user scheduling schemes and power allocation strategies into consideration. Specifically, the greedy user scheduling (GUS) and cumulative distribution function (CDF) based user scheduling (CUS) schemes are considered, which could maximize the rate performance and guarantee scheduling fairness, respectively. Meanwhile, we re-investigate cognitive power allocation (CPA) strategy, and propose a new rate fairness-oriented power allocation (FPA) strategy to enhance the scheduled users' rate fairness. By employing order statistics and stochastic geometry, an analytical expression of the outage probability for each scheduling scheme combining power allocation is derived to characterize the performance. To get more insights, the achieved diversity order of each scheme is also derived. Theoretical results demonstrate that both GUS and CUS schemes applying CPA or FPA strategy can achieve full diversity orders, and the application of CPA strategy in RSMA can effectively eliminate the secondary user's diversity order constraint from the primary user. Simulation results corroborate the accuracy of the analytical expressions, and show that the proposed FPA strategy can achieve excellent rate fairness performance in high signal-to-noise ratio region.Comment: 38 pages,8 figure

Mini percutaneous nephrolithotomy is a noninferior modality to standard percutaneous nephrolithotomy for the management of 20-40 mm renal calculi: A Multicenter randomized controlled trial

Background: High quality of evidence comparing mini percutaneous nephrolithotomy (mPNL) with standard percutaneous nephrolithotomy (sPNL) for the treatment of larger-sized renal stones is lacking. Objective: To compare the efficacy and safety of mPNL and sPNL for the treatment of 20–40 mm renal stones. Design, setting, and participants: A parallel, open-label, and noninferior randomized controlled trial was performed at 20 Chinese centers (2016–2019). The inclusion criteria were patients 18–70 yr old, with normal renal function, and 20–40 mm renal stones. Intervention: Percutaneous nephrolithotomy PNL was performed using either 18 F or 24 F percutaneous nephrostomy tracts. Outcome measurements and statistical analysis: The primary outcome was the one-session stone-free rate (SFR). The secondary outcomes included operating time, visual analog pain scale (VAS) score, blood loss, complications as per the Clavien-Dindo grading system, and length of hospitalization. Results and limitations: The 1980 intention-to-treat patients were randomized. The mPNL group achieved a noninferior one-session SFR to the sPNL group by the one-side noninferiority test (0.5% [difference], p < 0.001). The transfusion and embolization rates were comparable; however, the sPNL group had a higher hemoglobin drop (5.2 g/l, p < 0.001). The sPNL yielded shorter operating time (–2.2 min, p = 0.008) but a higher VAS score (0.8, p < 0.001). Patients in the sPNL group also had longer hospitalization (0.6 d, p < 0.001). There was no statistically significant difference in fever or urosepsis occurrences. The study's main limitation was that only 18F or 24F tract sizes were used. Conclusions: Mini mPNL achieves noninferior SFR outcomes to sPNL, but with reduced bleeding, less postoperative pain, and shorter hospitalization. Patient summary: We evaluated the surgical outcomes of percutaneous nephrolithotomy using two different sizes of nephrostomy tracts in a large population. We found that the smaller tract might be a sensible alternative for patients with 20–40 mm renal stones. This multicenter, parallel, open-label, and noninferior randomized controlled trial showed that mini percutaneous nephrolithotomy achieved noninferior stone-free rate with advantages of reduced blood loss, less postoperative pain, and shorter hospitalization. Mini percutaneous nephrolithotomy should be considered a sensible alternative treatment of 20–40 mm renal stones.grants from high-level development funding of Guangzhou Medical Universit

ULK1/2 Constitute a Bifurcate Node Controlling Glucose Metabolic Fluxes in Addition to Autophagy

揭示了在外界能量供应缺乏时，细胞通过激活ULK1来介导葡萄糖分解代谢重编程以维持胞内的能量与氧化还原稳态的详细机制，并创新地发现了ULK1独立于自噬的关键功能。基于自噬和糖代谢与人类健康的重要相关性，该研究将很可能为我们预防和治疗各类代谢疾病提供新的思路和药物靶点。Metabolic reprogramming is fundamental to biological homeostasis, enabling cells to adjust metabolic routes after sensing altered availability of fuels and growth factors. ULK1 and ULK2 represent key integrators that relay metabolic stress signals to the autophagy machinery. Here, we demonstrate that, during deprivation of amino acid and growth factors, ULK1/2 directly phosphorylate key glycolytic enzymes including hexokinase (HK), phosphofructokinase 1 (PFK1), enolase 1 (ENO1), and the gluconeogenic enzyme fructose-1,6-bisphosphatase (FBP1). Phosphorylation of these enzymes leads to enhanced HK activity to sustain glucose uptake but reduced activity of FBP1 to block the gluconeogenic route and reduced activity of PFK1 and ENO1 to moderate drop of glucose-6-phosphate and to repartition more carbon flux to pentose phosphate pathway (PPP), maintaining cellular energy and redox homeostasis at cellular and organismal levels. These results identify ULK1/2 as a bifurcate-signaling node that sustains glucose metabolic fluxes besides initiation of autophagy in response to nutritional deprivation.State Key Program of National Natural Science of China， the 973 Program；National Natural Science Foundation of China for Fostering Talents in Basic Research ；the Foundation for Innovative Research Groups of the National Natural Science Foundation of China； and the 111 Project of Education of China

Research on Complex Classification Algorithm of Breast Cancer Chip Based on SVM-RFE Gene Feature Screening

Screening and classification of characteristic genes is a complex classification problem, and the characteristic sequences of gene expression show high-dimensional characteristics. How to select an effective gene screening algorithm is the main problem to be solved by analyzing gene chips. The combination of KNN, SVM, and SVM-RFE is selected to screen complex classification problems, and a new method to solve complex classification problems is provided. In the process of gene chip pretreatment, LogFC and P value equivalents in the gene expression matrix are screened, and different gene features are screened, and then SVM-RFE algorithm is used to sort and screen genes. Firstly, the characteristics of gene chips are analyzed and the number between probes and genes is counted. Clustering analysis among each sample and PCA classification analysis of different samples are carried out. Secondly, the basic algorithms of SVM and KNN are tested, and the important indexes such as error rate and accuracy rate of the algorithms are tested to obtain the optimal parameters. Finally, the performance indexes of accuracy, precision, recall, and F1 of several complex classification algorithms are compared through the complex classification of SVM, KNN, KNN-PCA, SVM-PCA, SVM-RFE-SVM, and SVM-RFE-KNN at P=0. 01,0.05,0.001. SVM-RFE-SVM has the best classification effect and can be used as a gene chip classification algorithm to analyze the characteristics of genes

Stackelberg Game Based Power Control with Outage Probability Constraints for Cognitive Radio Networks

This paper firstly investigates the problem of uplink power control in cognitive radio networks (CRNs) with multiple primary users (PUs) and multiple second users (SUs) considering channel outage constraints and interference power constraints, where PUs and SUs compete with each other to maximize their utilities. We formulate a Stackelberg game to model this hierarchical competition, where PUs and SUs are considered to be leaders and followers, respectively. We theoretically prove the existence and uniqueness of robust Stackelberg equilibrium for the noncooperative approach. Then, we apply the Lagrange dual decomposition method to solve this problem, and an efficient iterative algorithm is proposed to search the Stackelberg equilibrium. Simulation results show that the proposed algorithm improves the performance compared with those proportionate game schemes